Student Seminar Series - July 28, 2005
University of Minnesota
School of Statistics
College of Liberal Arts
Analysis
of Children with Anaplastic Astrocytoma or Glioblastoma Multiforme
Treated with the “8-Drugs-In-One-Day” Regimen
(CCG Protocol 945)
Divah Yap
Thursday, July 28, 2005
2:00 PM, 155
Ford Hall
Minneapolis, East Bank Campus
Refreshments at 1:30 PM
300 Ford Hall
Abstract
Children’s Cancer Group (CCG) 945 is a randomized, prospective
study, comparing two treatment arms: the “8-drugs-in-one-day” regimen
and the control arm. Results of the trial were published in 1995. This
paper is a follow-up of CCG 945. It discusses the analysis of a subset
of patients with anaplastic astrocytoma or glioblastoma multiforme
enrolled in the study. This is of particular interest to the
investigators. The treatment groups were compared for patients’
progression of disease or death using Kaplan-Meier survival curves and
log-rank tests. Association of “time to relapse or death” with initial
tumor site, pathology, and other baseline variables is determined using
Cox regression models. Results of the comparison of the survival curves
showed that there is no statistically significant difference between
the treatment groups. With regards to association of “time to relapse
or death” with other baseline variables, only the extent of resection
has a statistically significant effect.